Fig. 5: Late-stage intervention with mRho ASO1 preserves functional performance in Prph2Y141C/+ mice. | Nature Communications

Fig. 5: Late-stage intervention with mRho ASO1 preserves functional performance in Prph2Y141C/+ mice.

From: Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders

Fig. 5

A Design of late-stage preclinical intervention studies. Created with BioRender.com released under a Creative Commons Attribution-Non-commercial-NoDervis 4.0 International license. B Representative scotopic and photopic waveforms recorded at 15- and 45-days post injections at P45. C, D Mean maximum amplitudes of scotopic a-waves and b-waves, as well as photopic a-waves and b-waves were plotted as mean ± SD for treated eyes (6.25 µg mRho ASO1) and vehicle control contralateral eyes in the late-stage intervention studies conducted at P60 and P90. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001 by Mann-Whitney U test (PI-45: N = 38 and PI-75: N = 18).

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