Fig. 1: Co/SPDO-catalyzed oxidative coupling/desymmetrization of phenols for synthesising chiral diaxial bridged biaryls.

a Representative bioactive compounds with an axially chiral bridged biaryl skeleton. b Catalytic enantioselective access to bridged biaryls. c Our design of Co/SPDO catalyzed aerobic oxidative coupling and desymmetrization of phenols.