Fig. 4: Preparation of bridged atropisomers with a single stereogenic axisa. | Nature Communications

Fig. 4: Preparation of bridged atropisomers with a single stereogenic axisa.

From: Atroposelective synthesis of biaxial bridged eight-membered terphenyls via a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization of phenols

Fig. 4

aReaction conditions: unless otherwise noted, the reactions were conducted with 1 (0.1 mmol), Co(OAc)2 (10 mol%), L1 (12 mol%), and DABCO (40 mol%), in acetone/EtOH (3 mL/1 mL), at −30 °C. bR6 = Mesitylene-2-sulfonyl. cR6 = Tosyl. Isolated yields. The ee values were determined by UPC2 or HPLC.

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