Fig. 5: Pathological diagnosis of lung tumors with the Au@Al2O3-Au-Au@Al2O3 trimer arrays.
From: Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors
a Schematic diagram of the reaction between aldehydes and 4-ATP on gold. b SERS spectra of 4-ATP on Au@Al2O3-Au-Au@Al2O3 trimers before (violet) and after (orange) reacting with discharged gas containing BA molecules. The C=N vibration mode suggesting the reaction is marked with a light green strip. c Anti-interference test of the Au@Al2O3-Au-Au@Al2O3 trimer samples exposed to BA, acetone, methanol, ethanol, acetonitrile, ethyl acetate, hexyl hydride and water. d, e Optical images of the ad-ca and sq-ca lung tumor tissues, respectively, after HE staining under a microscope. The scale bars are 50 μm. This experiment was independently repeated for all the tumor samples, and the results were similar. f Typical SERS spectra from the samples containing fresh ad-ca (red) or sq-ca cancer (violet) tissues, and blank sample (brown). g, h Raman mapping at 1623 cm−1 from the ad-ca and sq-ca samples (1600 points), respectively (step 1.5 μm, integral time 10 s), which color scales representing Raman intensities. Source data are provided as a Source Data file.
