Fig. 2: Substrate scope of the reactiona. | Nature Communications

Fig. 2: Substrate scope of the reactiona.

From: Copper-catalysed asymmetric annulation of yne-allylic esters with amines to access axially chiral arylpyrroles

Fig. 2

a C–C/C–N axially chiral arylpyrroles, b C–N axially chiral arylpyrroles. Reaction conditions: 1 (0.15 mmol), 2 (2.0 equiv., 0.3 mmol), Cu(CH3CN)4BF4 (10 mol%), L7 (12 mol%), MeOH (0.15 M), −10 °C. b −20 °C. c 1 (0.15 mmol), 2 (1.3 equiv., 0.195 mmol), Cu(CH3CN)4BF4 (10 mol%), L8 (12 mol%), DIPEA (1.5 equiv., 0.225 mmol), MeOH (0.15 M), −5 °C.

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