Fig. 6: Mechanism of PARP1-mediated DPC resolution. | Nature Communications

Fig. 6: Mechanism of PARP1-mediated DPC resolution.

From: PARP1-dependent DNA-protein crosslink repair

Fig. 6

A Illustration of PARP1-mediated targeting of TOP1cc-like lesions. B In the absence of repair (e.g., PARPi) TOP1cc-like lesions encountered on the leading strand template induce CMG run-off. C Unrepaired TOP1cc-like lesions encountered on the lagging strand template induce CMG disassembly.

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