Fig. 4: Substrate scope of hydroxylamine electrophiles. | Nature Communications

Fig. 4: Substrate scope of hydroxylamine electrophiles.

From: Enantioselective synthesis of γ-chiral amides via copper-catalyzed reductive relay hydroaminocarbonylation

Fig. 4

Reactions conditions: 1a (0.36 mmol), 2 (0.2 mmol), Cu(OAc)2 (5 mol%), (R)-DTBM-Segphos (7 mol%), CsF (3 equiv.), PMHS (4 equiv.), CO (10 bar), 60 °C and THF (1.0 mL). Isolated yields, ees were determined by chiral HPLC, and drs were determined by crude 1H NMR or chiral HPLC. aUse corresponding O-benzoylhydroxylamine as the electrophile. bUse corresponding O-pivaloylhydroxylamine as the electrophile. cUse (S)-DTBM-Segphos (7 mol%) as the ligand.

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