Fig. 1: Unidirectional blockade of the interhemispheric pathway using DREADDs.
From: Stage-dependent role of interhemispheric pathway for motor recovery in primates
A Reach and grasp task. B Experimental schedule. C Schematic diagrams of vector injections and the mechanism of unidirectional blockade of the interhemispheric pathway. D Representative RFP-labeled cells in the contralesional (left) PM of Monkey A. Rectangle indicates the area shown in (E). Scale bar, 200 µm. E High magnification view of D. Scale bar, 100 µm. F RFP-labeled fibers in the corpus callosum of Monkey A. Scale bar, 100 µm. G RFP-labeled fibers in the ipsilesional (right) PM of Monkey A. Rectangle indicates the area shown in (H). Scale bar, 100 µm. H High magnification view of (G). Scale bar, 20 µm. I Extent of the l-CST lesions. Lesions are indicated by black areas. The percentage indicates the proportion of the unilateral ventral and lateral funiculus that are lesioned. Scale bar, 1 mm. Rehab., rehabilitation. Similar images were obtained from three independent brain sections. (D, F, G).
