Fig. 2: Optimization of the reaction conditions. | Nature Communications

Fig. 2: Optimization of the reaction conditions.

From: Palladium-catalyzed cascade of aza-Wacker and Povarov reactions of aryl amines and 1,6-dienes for hexahydro-cyclopenta[b]quinoline framework

Fig. 2

aReaction conditions: 1a (0.2 mmol), 2a (0.2 mmol), PdCl2(10 mol%), L1 (20 mol%), NaBArF4 (30 mol%), 2,5-DTBQ (1.5 equiv.), and Al2O3 (60 mg) in DCM (0.1 M) at 70 oC under N2 atmosphere for 72 h. bYield was determined by 1H NMR of the crude product using CH2Br2 as internal standard. cIsolated yield. ArF = 3,5-(CF3)2C6H3. 2,5-DTBQ = 2,5-di-tert-butylcyclohexa-2,5-diene-1,4-dione.

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