Fig. 3: Orthogonal construction of stapled and bridged peptidesa. | Nature Communications

Fig. 3: Orthogonal construction of stapled and bridged peptidesa.

From: Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts

Fig. 3

aThe reaction was carried out with peptide 1 (1.0 eq.) and thianthrenium salt 2 (1.0 eq.) in DMSO/Tris-HCl buffer (v/v = 3:1) at room temperature for 1 h. bThe reaction was carried out with peptide 1 (2.0 eq.) and thianthrenium salt 2 (1.0 eq.) in DMSO/Tris-HCl buffer (v/v = 3:1) at room temperature for 1 h. Isolated yield after semipreparative HPLC was given. For details, see the Supplementary Information.

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