Fig. 2: Rates of apical and basal extrusion in one-event EMT-like scenarios.

a–l Rates of apical/basal extrusion and basal positioning after simulating one EMT-like event in cells with interkinetic movements (a–f) either individually (a–c) or in groups (d–f) or in cells without interkinetic movements (g–l) either individually (g–i) or in groups (j–l). The EMT-like events are loss of apical adhesion (A, gray lines), loss of basal adhesion (B, black lines), and loss of straightness (S, dotted lines). Data for control cells with no EMT-like event are plotted in green. The yellow area on each graph represents the time window of opportunity for EMT-like events to occur (see main text). Each simulation n = 500 for individual cells, n = 50 for groups of 11 cells. All graphs from panels a to l have the same X and Y axes scales, as labeled in a. Note that A (b, e) or loss of INM (h, k) leads to basal positioning while a combination of B and loss of INM leads to basal extrusion (i–l). m, n Scatter plots of rates of apical (Y-axis) and basal (X-axis) extrusion at t_final for scenarios with A (m) or B (n). Note that loss of INM (going from closed to open symbols) has more impact than passing from individual cells to groups (going from circles to squares). Also note that loss of INM has more impact when combined with B than with A. Source data are provided as a Source Data file.