Fig. 4: Cortical bistability in perilesional areas and its propagation to connected sites.
From: Sleep-like cortical dynamics during wakefulness and their network effects following brain injury
Mesoscale exploration of the effects of controlled surgical lesions performed in epileptic patients using radiofrequency-thermocoagulation (RFTC). RFTC (recorded with Stereo-EEG; SEEG) is followed by spontaneous sleep-like slow waves during wakefulness in cortical areas surrounding the lesion (black shade). This perilesional area (colored blue circles) showing prominent post-RFTC slow waves has a radius of about 30 mm, corresponding to the length of four adjacent SEEG bipolar contacts. The number and amplitude of RFTC-induced slow waves is maximal in close proximity to the lesion and rapidly decays with distance (color-coded with a deep-to-light blue gradient). Like slow waves typically found during physiological NREM sleep, these perilesional slow waves are associated with a suppression of high-frequency power >20 Hz (bottom left). Most importantly, post-RFTC slow waves can also be found at SEEG contacts (color-coded blue circles) that are distant (up to 60 mm) from the lesion but connected to it.
