Fig. 5: Pore fluctuation and evaporation.
From: Melittin can permeabilize membranes via large transient pores
a Snapshots of the final moments of the transmembrane pore of melittin, from one trajectory. Only 4 peptides remain, supporting a tiny water channel that ultimately dissolves (orange beads = lipid phosphate, water molecules = blue, blue sidechains = lysines). b Number of peptides in the pore Npore and the inner pore diameter dpore, throughout the simulation. The red dotted line indicates the pore closure event and gray area the non-pore simulation phase. c Peptide mass density distribution. d Ion and water flux. (green = CL-, purple = Na + ). e Center of mass insertion depth of all peptides. f Tilt angles of all peptides. S1, S2, TM1, TM2 denote the final peptide orientations after pore closure.
