Table 1 HCMV and cellular proteins that bind to oriG4-1 G4

From: G-quadruplex as an essential structural element in cytomegalovirus replication origin

HCMV proteinsa

Fold change (G4-Wt/G4-Mut)b

UL84

Replication initiator

24.43

UL44

DNA polymerase processivity factor

17.619

UL89

Terminase subunit 3

16.348

IE2

Replication initiator, transactivator

15.983

US22

Tegument protein

12.646

UL148

Membrane protein

3.437

Cellular proteinsa

 HNRNPH3

Heterogeneous nuclear ribonucleoprotein H3

50.875

 GRSF1

G-rich sequence factor 1

21.909

 RPL11

60S ribosomal protein L11

20.123

 HNRNPF

Heterogeneous nuclear ribonucleoprotein F

19.574

 HNRNPH2

Heterogeneous nuclear ribonucleoprotein H2

13.176

 RPS17

40S ribosomal protein S17

12.07

 DHX9

ATP-dependent RNA helicase A

11.371

 RPS3

40S ribosomal protein S3

8.248

 TCP1

T-complex protein1 subunit alpha

6.388

 RPS7

40S ribosomal protein S7

5.332

 RPS2

40S ribosomal protein S2

5.025

 KRT6A

Keratin, type II cytoskeletal 6A

2.446

 RPL5

60S ribosomal protein L5 (Fragment)

2.12

 PLEC

Plectin

1.688

  1. aHCMV and cellular proteins more effectively bound to G4 in oriG4-1 than in the unstructured oriG4-1m sequence (G4-Wt/G4-m > 1) in two independent experiments are shown
  2. bThe results of a representative experiment are shown.
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