Fig. 2: MTHFD2 localizes in the nucleus in multipotent healthy colon organoids.
From: Nuclear localization of MTHFD2 is required for correct mitosis progression
a Immunofluorescence of colon cancer (left) and multipotent healthy colon (right) patient-derived organoids. MTHFD2 is shown in green, VDAC1 (mitochondrial marker) in red and DAPI in gray; confocal mode; scale bar 50 μm. b Immunofluorescence of the multipotent healthy colon (left) and differentiated healthy colon (right) patient-derived colon organoids. MTHFD2 is shown in green, DAPI in gray, the proliferation marker Ki67 in yellow, and the differentiation marker Mucin-2 (MUC2) in magenta; confocal mode; scale bar 50 μm.
