Fig. 2: Clinicopathologic predictors and correlates of response to ICB.

a Violin plots showing the percentage of pathologic and radiologic tumour regression among patients with pre-operative low-grade tumour (grade 1 and 2) (n = 4) versus patients with a pre-operative high-grade tumour (grade 3) (n = 6). The white dots represent the means of the data, and the error bars indicate the 95% confidence intervals around the means. Statistical significance was assessed using the Mann–Whitney U test. b Violin plots depicting the percentage of pathologic and radiologic tumour regression among patients with MMRd caused by Lynch syndrome (n = 2) versus patients with a sporadic mutation (n = 8). The white dots represent the means of the data, and the error bars indicate the 95% confidence intervals around the means. Statistical significance was assessed using the Mann–Whitney U test. c Violin plots showing the percentage of pathologic and radiologic tumour regression among patients with a mutation in their MMR genes (n = 4) versus patients with hypermethylation of their MMR genes (n = 6). The white dots represent the means of the data, and the error bars indicate the 95% confidence intervals around the means. Statistical significance was assessed using the Mann–Whitney U test. d Dot plot showing the mutations per megabase (Mbase) among patients with a mutation in their MMR genes (n = 4) versus patients with hypermethylation of their MMR genes (n = 6) and showing the mutations per Mbase among patients with a MPR/pPR (n = 5) versus patients with NR (n = 5). e, Analysis of (potentially) pathogenic variants using TSO500, represented in an oncoprint format (n = 10). Mutations are visually differentiated by type, with the frequency of mutations per gene and per patient depicted. Source data are provided as a Source Data file. Abbreviations: G1,2,3 grade, MMRd mismatch repair deficiency, MPR major pathological response, pPR partial pathological response, NR non-responders.