Table 1 Antibiotic median MIC for Streptococcus mitis isolates from patients with IE across four 3-year intervals
Year | Number of isolates* | Median MIC (μg/mL) | Number of non-susceptible isolates and proportion (%) | P value** | |
|---|---|---|---|---|---|
Amoxicillin | 2001–2004 | 34 | 0.03 | 2 (5.9) | |
n = 97 | 2005–2008 | 21 | 0.06 | 4 (19.0) | |
2009–2012 | 25 | 0.03 | 2 (8.0) | ||
2013–2016 | 17 | 0.06 | 2 (11.8) | 0.06 | |
Cefotaxime | 2001–2004 | 38 | 0.06 | 2 (5.3) | |
n = 118 | 2005–2008 | 23 | 0.06 | 1 (4.3) | |
2009–2012 | 29 | 0.06 | 3 (10.3) | ||
2013–2016 | 28 | 0.125 | 0 (0) | 0.403 | |
Gentamicin | 2001–2004 | 38 | 6 | 0 (0) | |
n = 118 | 2005–2008 | 23 | 4 | 0 (0) | |
2009–2012 | 29 | 4 | 0 (0) | ||
2013–2016 | 28 | 2 | 0 (0) | 0.001 | |
Penicillin | 2001–2004 | 41 | 0.03 | 4 (9.8) | |
n = 129 | 2005–2008 | 28 | 0.064 | 10 (35.7) | |
2009–2012 | 29 | 0.03 | 6 (20.7) | ||
2013–2016 | 31 | 0.06 | 10 (32.3) | 0.111 | |
Vancomycin | 2001–2004 | 38 | 0.5 | 0 (0) | |
n = 118 | 2005–2008 | 23 | 0.5 | 0 (0) | |
2009–2012 | 29 | 0.5 | 0 (0) | ||
2013–2016 | 28 | 0.5 | 0 (0) | 0.230 |
