Fig. 5: In vivo DA sensing with Fe1/NC-900. | Nature Communications

Fig. 5: In vivo DA sensing with Fe1/NC-900.

From: Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst

Fig. 5

a CVs obtained at Fe1/NC-900-modified GCE in aCSF in the absence (gray) and presence (red) of 1 mM DA. Scan rate, 50 mV/s. b Plot of current response vs. DA concentration obtained with Fe1/NCs-modified GCEs. Applied potential, +0.20 V vs. Ag/AgCl. c CVs obtained at Fe1/NC-900-modified CFE in aCSF in the absence (gray) and presence (red) of 20 μM DA. Scan rate, 50 mV/s. d Amperometric response recorded at Fe1/NC-900-modified CFE toward successive additions of 5 μM DA in aCSF. Applied potential, +0.20 V vs. Ag/AgCl. Each experiment was repeated independently three times with similar results (a–d). Representative plots are shown. e Amperometric i-t curve recorded with Fe1/NC-900-modified CFE in rat NAc. f Typical amperometric response of Fe1/NC-900-modified CFE in rat NAc upon electrical stimulation of rat VTA (3 s at 60 Hz, ±300 μA) before (gray) and 25 min after (red) the rat were injected i.p. with a DA uptake inhibitor (NOM, 12 mg/kg). Applied potential, 0.20 V vs. Ag/AgCl. The in vivo experiments were repeated with 3 animals. Source data are provided with the paper.

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