Fig. 5: LIPPCPO-induced ferroptosis by DMT1 cysteinylation.
From: Synthetic vectors for activating the driving axis of ferroptosis
Lysosomal internalized LIPPCPO reacts with the cysteines at 245 and 248, 334 and 365 sites of DMT1 to form two cystines. This post-modification boosts the efflux function of DMT1 and exports more Fe2+ in cytoplasm, resulting in GSH depletion, GPX4 suppression and lipid peroxide accumulation. These events cumulate into ferroptosis.
