Fig. 3: ATF4 drives a metabolic gene expression signature. | Nature Communications

Fig. 3: ATF4 drives a metabolic gene expression signature.

From: Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis

Fig. 3

a Heatmap of protein coding gene expression changes in WT and ATF4 KO Dmr-PERK cells at the indicated time points following treatment with dimerizer (0.2 nM). Genes shown have a significantly altered time course between the two genotypes. Columns show the mean expression of three technical replicates relative to the mean expression at t = 0 on a log2 scale. Color bar indicates the class of each transcript based on the dose response study in Fig. 2. Gray boxes indicate genes that did not meet statistical significance in the dose response study from Fig. 2. b Selected GO terms with significant enrichment by ORA for the upregulated ATF4-dependent genes. Top 20 GO terms are in Supplementary Data 3.

Back to article page