Fig. 2: The genetic architecture of basal ganglia.
From: The genetic landscape of basal ganglia and implications for common brain disorders
A Schematic illustration of the basal ganglia regions, comprising the anatomically distinguishable subfields of putamen (pink), pallidum (light blue), caudate (red) and accumbens (green). Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license B The upper part of the Miami plot illustrates the −log10(P) statistic from the multivariate GWAS across the entire basal ganglia (Multivariate Omnibus Statistical Test (MOSTest)), with 72 significant loci. For comparison, the lower part depicts for each of the 72 unique loci the corresponding −log10(P) statistics from univariate GWASs of single subregions (one color per subregion, black indicates non-significant SNPs, p-values are two-tailed), supporting a distributed genetic architecture across the basal ganglia structure. The color codes for the schematic illustration (A) and the Miami plot (B) are consistent and given in the bottom part of the figure.
