Fig. 3: Scope of the reaction.
From: Construction of acenaphthylenes via C−H activation-based tandem penta- and hexaannulation reactions
Reactions run with 1 (0.1 mmol), 2 (0.4 mmol), [Cp*RhCl2]2 (5 mol%), AgOTf (20 mol%), CuO (0.3 mmol), 1-MeCHA (50 mol%), and DCE (2.0 mL) in a sealed 25 mL Schlenk tube under N2 atmosphere at 150 °C (oil bath) for 16 h. Hydrolysis conditions: 3 (0.1 mmol), KOH (2.0 mmol), and THF/H2O (2.0 mL, 1:1, v/v) in a sealed 25 mL Schlenk tube under N2 atmosphere at 100 °C (oil bath) for 24 h. Me: methyl; Et: ethyl; iBu: iso-butyl; Ph: phenyl; Bn: benzyl; Piv: pivaloyl; Cp*: 1,2,3,4,5-pentamethylcyclopentadiene; 1-MeCHA: 1-methylcyclohexane-1-carboxylic acid; OTf: trifluoromethanesulfonate; DCE: 1,2-dichloroethane.
