Fig. 4: Fish-hook catch bond design space.
a Catch regions of fish-hook catch bonds within the biologically relevant window of 0.01 <τ < 100 s and 0 <Fstart < 10 pN, simplified to a straight line between the lowest and highest τF. The tallest and widest catch behaviours are marked with * and #, respectively. b The characteristic Δlog(τF) and ΔF parameters of the catch regions. c, d The tallest and widest catch regions from (a, b). e Jaw lengths and CG contents that create catch behaviour are shown, coloured by the number of hook sequences that form catch bonds with them. The most versatile jaw, with a 0 bp CG content and a 27 bp length of (jaw0/27), is marked by a black box. f The hook sequence space that forms catch behaviour with the most versatile jaw in (e). g, h The same as (e, f), but for the hook design space and the jaws, which catch with the most versatile hook, which has an 8 bp CG content and an 8 bp length (hook8/8). Colours in (a–d, f, h) are coded by the 2D colour bar of the (b) inset.
