Fig. 4: Native structure of each OGDHc component.
From: Molecular architecture of the mammalian 2-oxoglutarate dehydrogenase complex
a Cryo-EM density map of the cubic core. The blue highlights the E2o symmetric units. b The monomer model for the E2o core domain. The secondary structure is labeled in the figure. H: helix, β: β-strand, T: turn. c Interactions in one homotrimer. The head interaction site (HI), side interaction site (SI), waist interaction site (WI), and tail interaction site (TI) are circled in the atomic model. d Interactions between two homotrimers. The hydrophobic pocket is circled in the interaction region. e Extra interactions in one homotrimer. f Extra interactions between two homotrimers. g E1o subtomogram averaging maps fitted with PDB: 7WGR. Densities of the linker region in E1o (S41-L128, D590 to S616, V362 to R379) are highlighted in the insets.
