Fig. 8: Activation of adenosine signaling restores LTP in astrocytic NLG3 KO mice. | Nature Communications

Fig. 8: Activation of adenosine signaling restores LTP in astrocytic NLG3 KO mice.

From: Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice

Fig. 8

a Adenosine restored LTP (ACSF n = 5 slices, 3 mice; adenosine n = 7 slices, 4 mice; p = 0.00394). b D-serine had no effect on LTP (ACSF n = 5 slices, 3 mice; D-serine n = 6 slices, 3 mice). c A2a agonist CGS 21680, not A1 agonist CPA, restored LTP (ACSF n = 5 slices, 3 mice; CPA n = 5 slices, 3 mice; CGS 21680 n = 5 slices, 3 mice; ACSF vs CGS 21680, p = 0.018; CPA vs CGS 21680, p = 0.014). d LTP rescue by adenosine blocked by A2a antagonist SCH 58261 (ACSF n = 5 slices, 3 mice; adenosine + SCH 58261 n = 5 slices, 3 mice). e ATP restored LTP (ACSF n = 5 slices, 3 mice; ATP n = 5 slices, 3 mice; p = 0.0139). f LTP rescue by ATP blocked by A2a antagonist SCH 58261 (ATP n = 5 slices, 3 mice; ATP + SCH 58261 n = 5 slices, 3 mice; p = 0.0311). g ATPγS or bzATP had no effects on LTP (ACSF n = 7 slices, 3 mice; bzATP n = 6 slice, 3 mice; ATPγS n = 5 slices, 3 mice). h Adenosine had no effect on LTP in WT mice (ACSF n = 5 slices, 3 mice, adenosine n = 5 slices, 3 mice). i A2a antagonist SCH 58261 blocked LTP in WT mice (ACSF n = 5 slices, 3 mice; SCH 58261 n = 5 slices, 3 mice; p = 0.000465). j A2a agonist CGS 21680 had no effect on LTP in WT mice (ACSF n = 5 slices, 3 mice; CGS 21680 n = 5 slices, 3 mice). Data represent mean ± SEM; two-tailed t test for (a, b, d, e, f, h, i, and j); one-way ANOVA with Holm-Sidak test for multiple comparisons for right panels of (c and g); *p < 0.05, **p < 0.01, ***p < 0.001. Scale bars: 0.25 mV/50 ms. Source data are provided as a Source Data file.

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