Fig. 1: Typical compounds containing chiral tertiary alcohols, the background for transition metal-catalyzed addition of ketones with organoborons, Petasis reaction and our design. | Nature Communications

Fig. 1: Typical compounds containing chiral tertiary alcohols, the background for transition metal-catalyzed addition of ketones with organoborons, Petasis reaction and our design.

From: Ni(II)-catalyzed asymmetric alkenylation and arylation of aryl ketones with organoborons via 1,5-metalate shift

Fig. 1

a Typical natural product and drug containing chiral tertiary alcohols. b Transition metal-catalyzed asymmetric alkenylation or arylation of ketones with organoborons (inner-sphere mechanism). c Petasis reaction. d Our design: asymmetric addition to ketones via a 1,5-metalate shift strategy (outer-sphere mechanism).

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