Fig. 4: The spatiotemporal detail of DUSK provides rich insights.
From: Deep-prior ODEs augment fluorescence imaging with chemical sensors
A Temporal median profile of the concentration and fluorescence responses to one action potential for the sensors jGCaMP8s (16 samples), jGCaMP8m (18 samples), and jGCaMP7f (12 samples). All the profiles were aligned with respect to the action potential (t = 0). Time points were plotted if there were more than 3 samples. Shaded areas indicate the interquartile (IQR) range. B Time difference between the rise times of the concentration and the duration of the corresponding n action-potential bursts. Box-and-whisker plots indicate the median and 25th–75th percentile range; bottom (top) whiskers indicate the smallest (largest) data value that is larger (smaller) than the 25th (75th) percentile ±1.5 IQR. Source data are provided as a Source Data file. C Spatially heterogeneous activity. Consecutive frames of measured (top row), predicted (middle row) fluorescence, and concentration (bottom row) for jGCaMP8s. For the sake of visualization, the concentration is displayed with the Hill coefficient (i.e., \({c}^{{n}_{{{\rm{H}}}}}\)). D Maps of time lag with two different time resolutions. The continuous temporal representation of DUSK allows us to sample the concentration at any rate. E Optimized latent vectors with L = 3. The frames with synaptic activities (golden dots) are clustered in the latent space even if they are apart in time.
