Fig. 7: Differential contribution of m1G9 to the folding of WT and variants of mt-Leu(UAA). | Nature Communications

Fig. 7: Differential contribution of m1G9 to the folding of WT and variants of mt-Leu(UAA).

From: Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology

Fig. 7

A model for differential contribution of m1G9 to the WT and variants of mt-Leu(UAA), represented by the A3243G and T3271C substitutions (cyan filled circles). While the addition of m1G9 (green filled circle) drives the WT tRNA to a correctly folded structure, it drives the A3243G variant to a mis-folded structure that differs from the correct structure in regions marked by red (closed circle). This model is also supported by the folding kinetics of the T3271C variant, although its structural variation has not been mapped (open circle).

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