Fig. 1: Overall study design.
From: GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma
Schematic diagram of the genomic SEM implemented in the GWAS-by-subtraction method. a The measured (observed) variables SNP, IOPcc, and POAG, indicated as rectangles, correspond to the SNP genotype, the observed IOPcc and the observed POAG case-control status for a sample population. Two latent variables, labeled IOP and non-IOP, are indicated as filled circles. The latent variables correspond to hypothetical (unobserved) factors that mediate the effect of the SNP on IOPcc and POAG. Straight arrows depict causal paths, while circular arrows indicate variances used to constrain the SEM. b Flowchart of the analysis process.
