Fig. 5: Results of the DCA support using MRP and readers assessment for making therapy-related decisions across NAT scenarios.

Left and Middle: The percentage of net interventions avoided per 1000 patients with non-pCR findings in Pre-/Mid-NAT (y-axis). The black curve (y = 0) of Pre-/Mid-NAT is a standard therapy-all approach (current clinical choice). Right: The percentage of net interventions avoided per 1000 patients with pCR (ypT0) findings in the Post-NAT (Pre-surgical) phase (y-axis). The black curve (y = 0) of Post-NAT is surgery-all approach (current clinical choice).