Fig. 1: Multi-omic analysis highlights the upregulated MVA pathway in BD-PMN. | Nature Communications

Fig. 1: Multi-omic analysis highlights the upregulated MVA pathway in BD-PMN.

From: TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

Fig. 1

A Lipidomic analysis between treatment-naïve BD and HC serum. B GSEA of steroid biosynthesis pathway in BD and HC peripheral blood immune cells, including bulk RNA-seq of PBMC (GSE198533), PMN (GSE205867), and single-cell RNA-seq of PBMC (GSE198616). C GSEA of steroid synthesis sub-pathways, including bile acids, steroid hormones, vitamin D, and cholesterol synthesis, in BD and HC PMN (GSE205867). D Heatmap showing enzyme expression of cholesterol synthesis pathway in BD PMN RNA-seq (GSE205867). Significantly increased and decreased genes are marked in red and blue, respectively. E Schematic plot showing the intervention of the cholesterol synthesis pathway. Significantly elevated enzymes validated by both BD PMN RNA-seq and qRT-PCR (N = 20) are marked in red. The agonists and inhibitors are marked by green and purple arrows, respectively. N for all experiments were biological replicates. ZGA, zaragozic acid; SQS, squalene synthase.

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