Fig. 1: Genetic and molecular characterizations of 3p21.1 locus in PGC3 BD GWAS.
From: NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice
A Genetic associations of SNPs spanning 3p21.1 region with BD in European populations (41917 cases and 371549 controls). A physical map of the region is given and depicts known genes within the region, and three independent risk SNPs (rs7622851, rs2336147 and rs2276824) were marked. The linkage disequilibrium (LD) of the three SNPs were calculated in European individuals from 1000 Genomes Project, based on the r2 algorithm implemented in SHEsis program. B Associations of rs7622851, rs2336147 and rs2276824 with mRNA expression of NEK4 in hippocampus (n = 371) from BrainSeq Phase 2 dataset. The BD risk-associated genotypes at each SNP were marked. In box plot B, the lines from top to bottom represent maximum, 3rd quartile, median, 1st quartile, and minimum, while the middle area represents the interquartile range. Source data are provided as a Source data file.
