Fig. 3: Pathway analysis for significantly and consistently up- and down-regulated metabolites (N = 18) that were reported in more than one study in newborn dried blood spot samples. | Nature Communications

Fig. 3: Pathway analysis for significantly and consistently up- and down-regulated metabolites (N = 18) that were reported in more than one study in newborn dried blood spot samples.

From: Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review

Fig. 3

The metabolome view shows all matched pathways according to the p values from the pathway enrichment analysis and pathway impact values from the pathway topology analysis. Each circle in the figure represents a metabolic pathway. The colour of the circle indicates the significance level (Raw p) in the enrichment analysis; darker colour (redder) indicates greater significance. The size of the circle reflects the pathway impact value in the topology analysis, such that the larger the circle, the larger the impact value. Three metabolic pathways were found to be significantly enriched in adjusted analyses (false discovery rate p value < 0.05): phenylalanine, tyrosine and tryptophan biosynthesis; valine, leucine and isoleucine biosynthesis; and phenylalanine metabolism. FDR false discovery rate. Source data are provided as a Source Data file.

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