Table 5 Significantly up-regulated and down-regulated metabolites that were reported in >1 study in neonatal samples

From: Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review

Metabolite

No. of studies

Up-regulated, No. of studies

Down-regulated, No. of studies

Newborn dried blood spot

Consistent trenda

Free carnitine

5

533,51,55,61,62

0

Butyryl carnitine

3

351,61,62

0

Acetyl carnitine

3

333,51,62

0

Decenoyl carnitine

3

351,61,62

0

Propionyl carnitine

3

0

351,61,62

Proline

3

355,61,62

0

Phenylalanine

2

251,62

0

Leucine

2

251,55

0

Glycine

2

251,62

0

Tyrosine

2

0

233,38

Valine

2

0

255,62

Arginine

2

0

262,68

Octadecadienyl carnitine

2

233,62

0

Isovaleryl carnitine

2

238,51

0

Tetradecanoyl carnitine

2

251,62

0

Dodecanoyl carnitine

2

261,62

0

Octadecanoyl carnitine

2

261,62

0

Octadecenoyl carnitine

2

261,62

0

Inconsistent trend

Alanine

6

533,51,55,61,62

168

Ornithine

6

438,55,61,62

238,68

Methionine

4

351,55,62

138

Citrulline

3

261,62

168

Octanoyl carnitine

3

261,62

168

Decanoyl carnitine

3

261,62

168

Dodecenoyl carnitine

2

161

168

Tetradecadienoyl carnitine

2

161

168

Hexadecenoyl carnitine

2

161

162

OH-Octadecenoyl carnitine

2

161

162

Malonyl carnitine

2

162

168

Hexanoyl carnitine

2

162

168

Acyl carnitine

2

162

168

Newborn urine

Consistent trenda

Myo-inositol

2

228,35

0

Creatinine

2

228,35

0

Creatine

2

228,35

0

Inconsistent trend

None

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  1. aThe trend of one metabolite was considered consistent if it showed the same direction of change in all studies.