Table 5 Significantly up-regulated and down-regulated metabolites that were reported in >1 study in neonatal samples
Metabolite | No. of studies | Up-regulated, No. of studies | Down-regulated, No. of studies |
---|---|---|---|
Newborn dried blood spot | |||
Consistent trenda | |||
Free carnitine | 5 | 0 | |
Butyryl carnitine | 3 | 0 | |
Acetyl carnitine | 3 | 0 | |
Decenoyl carnitine | 3 | 0 | |
Propionyl carnitine | 3 | 0 | |
Proline | 3 | 0 | |
Phenylalanine | 2 | 0 | |
Leucine | 2 | 0 | |
Glycine | 2 | 0 | |
Tyrosine | 2 | 0 | |
Valine | 2 | 0 | |
Arginine | 2 | 0 | |
Octadecadienyl carnitine | 2 | 0 | |
Isovaleryl carnitine | 2 | 0 | |
Tetradecanoyl carnitine | 2 | 0 | |
Dodecanoyl carnitine | 2 | 0 | |
Octadecanoyl carnitine | 2 | 0 | |
Octadecenoyl carnitine | 2 | 0 | |
Inconsistent trend | |||
Alanine | 6 | 168 | |
Ornithine | 6 | ||
Methionine | 4 | 138 | |
Citrulline | 3 | 168 | |
Octanoyl carnitine | 3 | 168 | |
Decanoyl carnitine | 3 | 168 | |
Dodecenoyl carnitine | 2 | 161 | 168 |
Tetradecadienoyl carnitine | 2 | 161 | 168 |
Hexadecenoyl carnitine | 2 | 161 | 162 |
OH-Octadecenoyl carnitine | 2 | 161 | 162 |
Malonyl carnitine | 2 | 162 | 168 |
Hexanoyl carnitine | 2 | 162 | 168 |
Acyl carnitine | 2 | 162 | 168 |
Newborn urine | |||
Consistent trenda | |||
Myo-inositol | 2 | 0 | |
Creatinine | 2 | 0 | |
Creatine | 2 | 0 | |
Inconsistent trend | |||
None | --- | --- | --- |