Fig. 6: Comparison of TM domain dimer conformations within the Trk family. | Nature Communications

Fig. 6: Comparison of TM domain dimer conformations within the Trk family.

From: Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB

Fig. 6

The spatial structures of TrkA (a, PDB 2N90 and TrkB (b, this work) TM dimers obtained by NMR in DPC micelles and DMPC/DHPC bicelles, respectively. Orange color denotes the residues on the experimentally determined interface. Green color indicates the residues proposed for the alternative dimerization interfaces, assumed from the cross-linking experiments20 (a) or computer modeling23 (b). c Manual sequence alignment of Trk family members based on the Clustal Omega program (http://www.clustal.org/) results for alignment of the transmembrane and intracellular domains. Experimentally determined TM domains are indicated, blue background highlights the identical residues.

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