Fig. 3: The time courses of visual stimulation evoked BOLD fMRI from ROIs of Allen brain atlas. | Nature Communications

Fig. 3: The time courses of visual stimulation evoked BOLD fMRI from ROIs of Allen brain atlas.

From: Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice

Fig. 3

A The functional maps overlaid with the brain atlas highlight activated brain regions: visual cortex (VC), superior colliculus (SC), retrosplenial cortex (RSP), lateral geniculate nucleus (LGN), and anterior cingulate area (ACA) from Alzheimer’s disease (AD) and wild-type (WT) mice. (Two-sided t-test p < 0.001, FDR < 0.01, minimum cluster size=200 voxels.) B The averaged time course based on the ROIs from brain atlas, demonstrating the evoked positive BOLD signal changes with the 8 s visual stimulation (5 Hz 530 nm and 5.1 Hz 490 nm 20 ms light pluses). Each graph displays the average of 116 sets of 5 stimulation epochs for 13 WT mice and 120 sets of 5 stimulation epochs for 9 AD mice. Shaded regions represent standard error. Cyan shadows represent the 8 s stimulation duration (WT: n = 13 mice with 58 trials; AD: n = 9 mice with 60 trials). Source data are provided as a Source Data file.

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