Fig. 4: Differential analysis of Pc-based fMRI correlation maps between wild-type (WT) and Alzheimer’s disease (AD) mice. | Nature Communications

Fig. 4: Differential analysis of Pc-based fMRI correlation maps between wild-type (WT) and Alzheimer’s disease (AD) mice.

From: Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice

Fig. 4

A The brain-wide Pc-based fMRI differential maps (WT-AD) show significantly higher BOLD signals detected along visual pathways in WT mice compared to AD mice (WT: n = 9 mice with 20 sessions; AD: n = 9 mice with 19 sessions; two-sided t-test p < 0.001, Permutation-based FDR < 0.001, minimum cluster size=200 voxels). B The enlarged functional maps overlaid with the brain atlas highlight the higher-order visual pathways: visual cortex (V1, V2), retrosplenial cortex (A30, A29), and lateral geniculate nucleus (LGN). Source data are provided as a Source Data file.

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