Fig. 5: Differential analysis of Pd-based fMRI correlation maps between wild-type (WT) and Alzheimer’s disease (AD) mice. | Nature Communications

Fig. 5: Differential analysis of Pd-based fMRI correlation maps between wild-type (WT) and Alzheimer’s disease (AD) mice.

From: Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice

Fig. 5

A The averaged brain-wide \({P}_{d}\)-based correlation maps of WT and AD mice (left panel: WT, n = 9 mice with 20 sessions; middle panel: AD, n = 9 mice with 19 sessions), and the differential maps between WT and AD mice (right panel: WT-AD) (two-sided t-test p < 0.04, Permutation-based FDR < 0.04, minimum cluster size = 200 voxels). B The differential maps overlaid with the brain atlas, highlighting brain regions with significant differences: midbrain raphe nuclei (MnR), hippocampus (CA1, DG), retrosplenial cortex (RSP), and lateral septal nucleus (LS). Source data are provided as a Source Data file.

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