Fig. 7: Substrate scope of aldehydes. | Nature Communications

Fig. 7: Substrate scope of aldehydes.

From: Palladium catalyzed ortho-C(sp2)–H activation/cyclization of aryl amines assisted by imine and vinylacetic acid

Fig. 7

aReaction conditions: 1 (0.25 mmol), 2a (1.5 equiv.), 3 (1.5 equiv.), Pd(TFA)2 (5 mol%), 2,6-DMBQ (1.0 equiv.), DMSO (0.5 M), at 35 °C under air for 24 h. Yield refers to isolated yield. dr (4’:4”) ratio was determined by 1H NMR of the crude product with MeNO2 as internal standard. b1a (0.25 mmol), 2 (1.5 equiv.), 3 (1.5 equiv.), Pd(TFA)2 (5 mol%), 2,9-dmphen (7.5 mol%), AcOH (0.5 mL), at 35 °C under air for 12 h. cTBHP (5.5 M in decane, 1.0 equiv.) was added.

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