Fig. 8: Synthetic applications. | Nature Communications

Fig. 8: Synthetic applications.

From: Palladium catalyzed ortho-C(sp2)–H activation/cyclization of aryl amines assisted by imine and vinylacetic acid

Fig. 8

a Late-stage functionalization of pharmaceutical molecules or natural products; b Synthetic applications. Reaction conditions: (a) 1a, 2a, 3, Pd(TFA)2, 2,9-dmphen, AcOH, at 35 °C under air for 12 h. (b) 1c, 2a, 3, Pd(TFA)2, 2,6-DMBQ, DMSO, at 35 °C under air for 24 h. c 4a, DIBAL-H (diisobutylaluminium hydride), CH2Cl2, at −78 °C under N2 for 1 h. d 4c, (triisopropylsilyl)acetylene, Pd(PPh3)2Cl2, CuI, Et3N, at 25 °C under N2 for 12 h. e 4c, tributyl(vinyl)tin, Pd(PPh3)4, toluene, at 120 °C under N2 for 12 h. f 4c, carbazole, CuI, 1,2-diaminocyclohexane, K3PO4, 1,4-dioxane at 90 °C under N2 for 24 h.

Back to article page