Fig. 3: Potential targets for liver regeneration. | Nature Communications

Fig. 3: Potential targets for liver regeneration.

From: Long-term machine perfusion of human split livers: a new model for regenerative and translational research

Fig. 3

Liver splitting and long-term perfusion provide the opportunity to induce liver regeneration and potentially improve partial organs prior to transplant. Multiple pathways have shown potential as mechanisms for liver regeneration, including phosphatase and tensin homologue (PTEN) inhibition, Hippo/Yap and Wnt-pathway activation, stem cell treatments, and modulation of cellular membrane potentials. An ex situ model of long-term perfusion of split livers allows a detailed study of liver regeneration and testing of these potential targets.

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