Fig. 2: Tank/Azi2DKO mice develop severe autoinflammation.
a, b Translations of DNA sequences (a) and an example of routine PCR genotyping (b) of the indicated Tank and Azi2 alleles. c Genotype and counts of pups born to parents of the indicated genotypes, two-tailed chi-square test. d, e Representative photographs of mice of the indicated genotype at the age of 4 weeks (d) and 20 weeks (e). f Survival curves of mice of the indicated genotype (n = 15 per group), log-rank Mantel-Cox test. g–i Tissue sections stained with H&E or the indicated dye. Skin (g), kidney (h), or liver (i) samples were collected from 20-24-week-old mice of the indicated genotype. Representative images are based on the analysis of five mice per group. j–n The concentration of different biochemical markers in the blood plasma collected from 20-24-week-old mice of the indicated genotype (n = 6 per group), mean + SEM, one-way ANOVA (p-value is shown) with Tukey’s post-tests. n.s., not significant. The scale bar is 100 µm.
