Fig. 8: Regulation of TBK1 activity by adapters TANK and AZI2. | Nature Communications

Fig. 8: Regulation of TBK1 activity by adapters TANK and AZI2.

From: TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases

Fig. 8

a, b Schematic representation of the differential recruitment of TANK and AZI2 to TNF-RSC. NEMO is recruited to K63- and M1-ubiquitin linkages formed by cIAP1/2 and LUBAC, respectively. NEMO is associated with TANK-TBK1 and promotes recruitment of A20, which enables recruitment of AZI2-TBK1 (a). At a later time, NEMO and TANK-TBK1 are released from the TNF-RSC. However, A20 remains associated with the TNF-RSC due to M1-binding and keeps recruiting AZI2-TBK1 (b).

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