Fig. 6: Whole-transcriptome analysis of gene expression in the retina of WT and Gpatch11Δ5/Δ5 mice.
From: GPATCH11 variants cause mis-splicing and early-onset retinal dystrophy with neurological impairment
a Volcano plot displaying differentially expressed genes between Gpatch11Δ5/Δ5 and wild-type (WT) mice. The x-axis represents the difference in gene expression fold change (FC) on a log2 scale, while the y-axis indicates the false discovery rate (FDR) adjusted significance on a log10 scale. Genes significantly upregulated are shown in orange, while downregulated genes are in blue. b Circular visualization depicting selected Gene Ontology (GO) enriched pathways. Up- (red dots) and downregulated genes (blue dots) within each GO pathway are plotted based on logFC. Z score bars indicate whether an entire biological process is more likely to be increased or decreased based on its constituent genes. c Heatmaps from Metascape displaying the GO pathways of interest. Blue represents low expression, while orange represents high expression. The raw data is accessible via BioStudies identifier S-BSST1157.
