Fig. 1: Tolerance in cancer cells in response to chemotherapy.
From: Early tolerance and late persistence as alternative drug responses in cancer
a Time-kill curves of three PDOs from mCRC patients treated with FOLFOX or FOLFIRI (n=mean of three experimental replicates ± SD). Time-kill curves of HCT116 (b) and HT29 (c) CRC cells in response to FOLFOX or FOLFIRI (n=mean of three experimental replicates ± SD). Time-kill curves of MDA-MB-231 and MBC26 patient-derived xenograft breast cancer cells (d) treated with cisplatin and two models of primary ovarian cancer cells (OC_AS05 and OC_AS17) treated with carboplatin and paclitaxel (CPT + PTX) (e). The drugs concentrations ranged from the half maximal inhibitory concentration (IC50) to 50- to 100-fold higher. Cell viability was measured at 0, 16, 24, 48, 72 and 120 hours (hrs). Fraction of surviving cells (expressed in Log10 scale) was calculated for each concentration at each time point with respect to the time zero (n=mean of three experimental replicates ± SD). f Dose response curve of NCI-H23 lung cancer cells to cisplatin 5 μg/ml (n = 3 experimental replicates; mean ± SD). Source data are provided as a Source Data file.
