Fig. 2: PAM binding mode of VU0155041.
From: Structural basis of orientated asymmetry in a mGlu heterodimer
a Comparison of the PAM binding pocket in mGlu4 and mGlu2 subunit. The mGlu4 PAM VU0155041 is shown as magenta sticks. The mGlu2 PAM JNJ-40411813 is shown as yellow sticks. b Detailed binding mode of VU0155041 in mGlu4 subunit. c Potency (pEC50) of Glu with or without VU0155041 on mGlu2-4 chimeric heterodimer (composed of mGlu2C1 and mGlu4C2, referred as Ctr) and the indicated mutants. Data points represent mean ± s.e.m. from independent experiments (n = 3, 5, 4, 3, 3, 4, 4, 4, 4) and analyzed using unpaired student t test (two-tailed) to determine significance between pEC50 of Glu without and with VU0155041 treatment for each receptor. ***P < 0.001, not significant (ns) >0.05. P values for (c): 0.0042, 0.5357, 0.3131, 0.1191, 0.6036, 0.6994, 0.0884, 0.3710, 0.2541 (from left to right). Source data are provided as a Source Data file.
