Fig. 8: The effect of rs74512655 on OSGEP transcriptional activity. | Nature Communications

Fig. 8: The effect of rs74512655 on OSGEP transcriptional activity.

From: OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice

Fig. 8

a Overview of the pGL3-rs74512655 reporter plasmid constructs used for dual luciferase assays. b The relative firefly luciferase activities were compared between pGL3-G and pGL3-C group (n = 3). c Overview of the OSGEP promoter-rs74512655 reporter plasmid constructs used for dual luciferase assays. (d) Relative firefly luciferase activities in constructs containing OSGEP promoter driven by DNA fragment harboring rs74512655 (n = 3). b, d Data are presented as the mean ± SD. b, d Unpaired two-tailed Student’s t-test. **p < 0.01; ****p < 0.0001. Source data are provided as a Source Data file.

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