Fig. 3: Development of skin lesions and pathological damage in AR-MPXV5- or sham-immunized macaques after MPXV challenge.
From: A penta-component mpox mRNA vaccine induces protective immunity in nonhuman primates
a Photographs of skin lesions from three animals in the sham group at 10 dpi. b Skin lesions were counted at 0, 4, 7, and 10 dpi. n = 3 independent biological replicates (Sham), n = 4 independent biological replicates (AR-MPXV5). Data are shown as the mean ± SEM. Statistical differences were analyzed by using two-way ANOVA. ****P < 0.0001. c H&E staining of skin samples from MPXV-infected macaques. Yellow arrows: epidermis exhibited an increased thickness accompanied by spinous layer hypertrophy and vacuolar degeneration of spinous cells. Black arrows: cell necrosis in the epidermis and superficial dermis. Green arrows: disorganization of collagen fibers within the dermal layer. Red arrows: infiltration of numerous granulocytes, lymphocytes, and macrophages in dermal layer. Source data are provided as a Source Data file.
