Fig. 4: Protective efficacy of MPXV mRNA vaccine in cynomolgus macaques.
From: A penta-component mpox mRNA vaccine induces protective immunity in nonhuman primates
a–d Viral DNA loads in plasma (a), urine (b), nasal swab (c) and throat swab (d) at 0, 1, 4, 7, and 10 dpi. n = 3 independent biological replicates (Sham), n = 4 independent biological replicates (AR-MPXV5). Data are shown as the mean ± SEM. Statistical differences were analyzed by using two-way ANOVA. *P < 0.05, ***P < 0.001. The exact P values are: P = 0.0106 (a), P = 0.0004 (b), P = 0.0005 (c) and P = 0.0107 (d). e Viral DNA copies in tissues after MPXV challenge at 10 dpi. f Viral loads in tissues after MPXV challenge at 10 dpi by using plaque forming assay. Source data are provided as a Source Data file.
