Fig. 5: Cytokine expression and antibody response pre- and post-challenge in AR-MPXV5- or sham-immunized macaques.
From: A penta-component mpox mRNA vaccine induces protective immunity in nonhuman primates
a Cytokine and chemokine expressions were determined by Luminex and presented as fold changes compared to samples collected before challenge. b Concentrations of IFN-γ, SDF-1α and VEGF-A in plasma samples pre- and post-challenge. n = 3 independent biological replicates (Sham), n = 4 independent biological replicates (AR-MPXV5). Data are shown as the mean ± SEM. Statistical differences were analyzed by using two-way ANOVA. *P < 0.05, ***P < 0.001, ****P < 0.0001. The exact P values are: P < 0.0001 (IFN-γ, day 4), P = 0.0003 (SDF-1α, day 7), P = 0.0003 (VEGF-A, day 7) and P = 0.0323 (VEGF-A, day 10). c Neutralizing antibody titers against VACV in serum samples 10 days pre- and post-challenge. Source data are provided as a Source Data file.
